MED10
Description
The MED10 (mediator complex subunit 10) is a protein-coding gene located on chromosome 5.
MED10 is a protein encoded by the MED10 gene in humans. It is a component of the Mediator complex, a coactivator that helps activate transcription via RNA polymerase II.
MED10 is a component of the Mediator complex, a crucial coactivator that regulates transcription of almost all genes dependent on RNA polymerase II. It acts as a bridge, transmitting information from specific regulatory proteins to the basic RNA polymerase II transcription machinery. Mediator attaches to promoters through direct interactions with regulatory proteins and serves as a framework for building a functional preinitiation complex with RNA polymerase II and essential transcription factors.
MED10 is also known as L6, NUT2, TRG20.
Associated Diseases
- hemoglobin D disease
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
- hemoglobin E disease
- dominant beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
- delta-beta-thalassemia
- thrombocytopenia, anemia, and myelofibrosis
- alpha-thalassemia-myelodysplastic syndrome
- primary familial polycythemia due to EPO receptor mutation
- hemoglobin C-beta-thalassemia syndrome
- ghosal hematodiaphyseal dysplasia
- hemoglobin H disease
- bone marrow failure syndrome 6
- monosomy 7 myelodysplasia and leukemia syndrome 1
- beta-thalassemia-X-linked thrombocytopenia syndrome
