MED20
Description
The MED20 (mediator complex subunit 20) is a protein-coding gene located on chromosome 6.
Mediator complex subunit 20 (Med20) is a protein encoded by the MED20 gene in humans. Mutations in the MED20 gene are associated with basal ganglia degeneration and brain atrophy in infants.
MED20 is a component of the Mediator complex, a vital coactivator in the transcription of almost all genes dependent on RNA polymerase II. The Mediator complex acts as a bridge, relaying information from gene-specific regulatory proteins to the fundamental RNA polymerase II transcription machinery. It achieves this by directly interacting with regulatory proteins to bind to promoters, effectively serving as a scaffold for assembling a functional preinitiation complex alongside RNA polymerase II and general transcription factors.
MED20 is also known as PRO0213, SRB2, TRFP.
