MEIKIN
Description
The MEIKIN (meiotic kinetochore factor) is a protein-coding gene located on chromosome 5.
MEIKIN is a crucial regulator of kinetochore function during meiosis I. It plays a dual role: ensuring proper mono-orientation of sister kinetochores towards the same spindle pole, and safeguarding centromeric cohesin from premature separase-mediated cleavage. This protection is likely achieved through the shugoshin-dependent pathway, which MEIKIN may regulate. Notably, MEIKIN collaborates with PLK1 by facilitating its accumulation at kinetochores. Its function is meiosis-specific and not required during meiosis II or mitosis.
MEIKIN is also known as SPO13.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- asthma
- spermatogenic failure 48
- congenital bilateral absence of vas deferens
- spermatogenic failure 74
- spermatogenic failure 73
- spermatogenic failure 61
- spermatogenic failure 25
- spermatogenic failures 50
- spermatogenic failure 1
- spermatogenic failure 40
- spermatogenic failure, X-linked, 3
