METTL21B
Mettl21b: An Essential Gene for Cellular Regulation
Description
Mettl21b is a gene that encodes a protein of the same name. This protein is involved in the modification of RNAs, specifically by adding a methyl group to the N6 position of adenosine. This modification is known as m6A and is prevalent in coding and non-coding RNAs. Mettl21b plays a crucial role in regulating gene expression, cell growth, and development.
Associated Diseases
Mutations in the Mettl21b gene have been linked to several diseases, including:
- Intellectual disability: Mettl21b mutations can lead to intellectual disability and developmental disorders, such as Angelman syndrome.
- Cancer: Alterations in Mettl21b expression have been associated with various types of cancer, including leukemia, breast cancer, and lung cancer.
- Neurological disorders: Mettl21b mutations have been implicated in autism spectrum disorder and schizophrenia.
Did you Know ?
- m6A is the most prevalent internal RNA modification in eukaryotes, with over 10,000 m6A sites identified in the human genome.
