MLLT4
Description
MLLT4, also known as AF4, is a gene that encodes a protein involved in the regulation of gene expression. It plays a critical role in hematopoiesis, the process of blood cell development. MLLT4 is commonly involved in chromosomal translocations, particularly in acute leukemia, where it fuses with the MLL gene, creating a chimeric protein that contributes to uncontrolled cell growth and leukemia development.
Associated Diseases
- Acute Lymphoblastic Leukemia (ALL)
- Acute Myeloid Leukemia (AML)
- Myelodysplastic Syndromes (MDS)
- T-cell Lymphoblastic Lymphoma (T-LBL)
Did you know?
MLLT4 is a common translocation partner for the MLL gene, involved in more than 50% of cases of infant ALL.
