MNX1
Description
The MNX1 (motor neuron and pancreas homeobox 1) is a protein-coding gene located on chromosome 7.
MNX1, also known as Homeobox HB9, is a human protein produced by the MNX1 gene. Mutations in this gene are associated with Currarino syndrome. Higher levels of MNX1-AS1 long noncoding RNA are linked to a worse prognosis in gastric cancer.
MNX1 acts as a transcription factor, binding to regulatory elements of target genes like CHX10, inhibiting their transcription. It collaborates with LMO4 to establish motor neuron identity, and plays a role in suppressing interneuron gene expression in motor neurons by interfering with ISL1-LHX3 complex interactions. MNX1 is involved in pancreatic development and function, potentially influencing pancreatic cell fate determination.
MNX1 is also known as HB9, HLXB9, HOXHB9, SCRA1.
