MTHFD2
Description
The MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) is a protein-coding gene located on chromosome 2.
The MTHFD2 gene encodes a nuclear-encoded mitochondrial bifunctional enzyme, responsible for both methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. This enzyme operates as a homodimer and uniquely requires magnesium and inorganic phosphate for its activity. The formation of the enzyme-magnesium complex facilitates NAD binding. The gene undergoes alternative splicing, resulting in various transcripts encoding different isoforms. Furthermore, a pseudogene of this gene is located on chromosome 7.
MTHFD2 is also known as NMDMC.
