MYT1

• SHARE NOW |
• Tweet Opens in a new window.
• Pin it Opens in a new window.
• Share Opens in a new window.
• Share Opens in a new window.
• Email Opens in a new window.

Description

The MYT1 (myelin transcription factor 1) is a protein-coding gene located on chromosome 20.

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene. The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. MYT1 has been shown to interact with PIN1.

Myelin transcription factor 1 (MyT1) binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. This protein may play a role in the development of neurons and oligodendroglia in the central nervous system. It may also regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

MYT1 is also known as C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2H2C1, ZC2HC4A.

Associated Diseases

• hereditary spastic paraplegia
• asthma
• lethal congenital contracture syndrome 3
• diaphragmatic hernia 3
• schizophrenia