NAAA
Description
The NAAA (N-acylethanolamine acid amidase) is a protein-coding gene located on chromosome 4.
NAAA breaks down bioactive fatty acid amides into their corresponding acids, with a preference for N-palmitoylethanolamine, followed by N-myristoylethanolamine, then N-lauroylethanolamine and N-stearoylethanolamine, with weaker activity towards N-arachidonoylethanolamine and N-oleoylethanolamine. NAAA also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.
NAAA is also known as ASAHL, PLT.
Associated Diseases
- hemoglobin E-beta-thalassemia syndrome
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- microcytic anemia with liver iron overload
- primary familial polycythemia due to EPO receptor mutation
- alpha-thalassemia-myelodysplastic syndrome
- hemoglobin D disease
- alpha thalassemia-intellectual disability syndrome type 1
- hemochromatosis type 5
- delta-beta-thalassemia
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- dominant beta-thalassemia
- gluthathione peroxidase deficiency
- hemoglobin C-beta-thalassemia syndrome
