NAGK
Description
The NAGK (N-acetylglucosamine kinase) is a protein-coding gene located on chromosome 2.
NAGK (N-acetyl-D-glucosamine kinase) is an enzyme encoded by the NAGK gene in humans. It converts N-acetylglucosamine (GlcNAc) into GlcNAc 6-phosphate, a key step in amino sugar metabolism. NAGK interacts with STK16 and LNX1.
NAGK converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It plays a role in the degradation of N-glycolylneuraminic acid (Neu5Gc), which is present in food but cannot be produced by humans. Additionally, NAGK has N-acetylmannosamine (ManNAc) kinase activity. It is also involved in innate immunity by promoting the detection of bacterial peptidoglycan by NOD2. NAGK catalyzes the phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2.
NAGK is also known as GNK, HSA242910.
Associated Diseases
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 3
- permanent neonatal diabetes mellitus 1
- megaloblastic anemia, folate-responsive
- congenital enteropathy due to enteropeptidase deficiency
- multiple sclerosis
- Huntington disease
- cancer
