NAT8
Description
The NAT8 (N-acetyltransferase 8 (putative)) is a protein-coding gene located on chromosome 2.
N-acetyltransferase 8 is a protein encoded by the NAT8 gene in humans. Mutations in NAT8 have been linked to chronic kidney disease.
NAT8 catalyzes the acetylation of cysteine S-conjugates to form mercapturic acids, a crucial step in detoxification of reactive electrophiles. This process starts with glutathione S-conjugate formation and progresses through cysteine S-conjugate intermediates, ultimately leading to water-soluble mercapturic acids that are excreted in urine or bile. Additionally, NAT8 may exhibit lysine N-acetyltransferase activity, acetylating peptidyl-lysine residues in various proteins. This activity could regulate apoptosis by influencing PROM1 expression and acetylation. Furthermore, NAT8 might regulate amyloid beta-peptide secretion through acetylation and expression regulation of BACE1 in neurons.
NAT8 is also known as ATase2, CCNAT, CML1, GLA, Hcml1, TSC501, TSC510.
