NCEH1
Description
The NCEH1 (neutral cholesterol ester hydrolase 1) is a protein-coding gene located on chromosome 3.
Neutral cholesterol ester hydrolase 1 (NCEH), also known as arylacetamide deacetylase-like 1 (AADACL1) or KIAA1363, is an enzyme encoded by the NCEH1 gene. Located in the endoplasmic reticulum, NCEH hydrolyzes 2-acetyl monoalkylglycerol ether, a step in the pathway regulating platelet activating factor and lysophospholipids, potentially involved in cancer development. NCEH converts 2-acetyl monoalkylglycerol ether to monoalkylglycerol ether, which can then be transformed into alkyl-lysophosphatidic acid (alkyl-LPA) and alkyl-lysophosphatidylcholine (alkyl-LPC). While some studies suggest NCEH hydrolyzes cholesterol esters, loss of NCEH in mice primarily affects 2-acetyl monoalkylglycerol ether activity. NCEH plays a role in cancer, with cancer cell lines exhibiting high NCEH levels. Reducing NCEH1 in cancer cells decreases tumor migration and growth in mice, while adding alkyl-LPA reverses this effect. NCEH can also degrade organophosphates like chlorpyrifos oxon.
NCEH1 is also known as AADACL1, NCEH.
