NFATC2
Description
The NFATC2 (nuclear factor of activated T cells 2) is a protein-coding gene located on chromosome 20.
NFATC2, also known as NF-ATc2, NFATc2, NFAT pre-existing subunit, and T-cell transcription factor NFAT1, is a protein encoded by the NFATC2 gene in humans. It's a member of the NFAT family, which are DNA-binding proteins involved in the immune response. NFATC2 is present in the cytosol and translocates to the nucleus upon T-cell receptor (TCR) stimulation, forming part of the NFATC transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Different isoforms of NFATC2 are encoded by alternative splicing. A translocation involving EWSR1 and NFATc2 has been associated with bone tumors with an Ewing sarcoma-like appearance. This translocation leads to constant activation of the NFATc2 protein. NFATC2 interacts with various proteins, including MEF2D, EP300, IRF4, and Protein kinase Mζ. Prostaglandin F2alpha stimulates a NFCT2 pathway, promoting growth of skeletal muscle cells.
NFATC2 plays a crucial role in regulating the expression of cytokine genes in T-cells, particularly in the production of IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. It also promotes invasive migration by activating GPC6 expression and the WNT5A signaling pathway, while negatively regulating chondrogenesis. These functions are supported by various studies (PubMed:15790681, PubMed:21871017, PubMed:35789258).
NFATC2 is also known as JCOSL, NFAT1, NFATP.
