NGFRAP1
ngfrap1: Unraveling the Neurotrophin Receptor's Role in Neurobiology and Disease
Description
ngfrap1 (nerve growth factor receptor alpha polypeptide 1) is a gene that encodes a protein called the p75 neurotrophin receptor (p75NTR). This receptor is primarily associated with the nervous system and plays a crucial role in regulating neuronal development, survival, and death.
Associated Diseases
neurodegenerative disorders:
- Alzheimer's disease
- Parkinson's disease
- Amyotrophic lateral sclerosis (ALS)
developmental disorders:
- Autism spectrum disorder (ASD)
- Rett syndrome
Did you Know ?
Approximately 15% of patients with Alzheimer's disease carry mutations in the ngfrap1 gene. These mutations have been linked to increased susceptibility and earlier onset of the disease.
