NKAP

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Description

The NKAP (NFKB activating protein) is a protein-coding gene located on chromosome X.

NKAP, or NF-kappa-B-activating protein, is a protein encoded by the NKAP gene in humans.

NKAP acts as a transcriptional repressor, playing a role in the repression of Notch-mediated signaling essential for T-cell development. It is also involved in the activation of NF-kappa-B induced by TNF and IL-1. NKAP associates with chromatin at the Notch-regulated SKP2 promoter.

NKAP is also known as MRXSHD.

Associated Diseases

• Intellectual developmental disorder, X-linked, syndromic, Hackman-Di Donato type