NOL3
Description
The NOL3 (nucleolar protein 3) is a protein-coding gene located on chromosome 16.
Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene. Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation. Paradoxically, loss of Nol3 also leads to hematological disruption in mice resulting in a myeloproliferative neoplasm resembling primary myelofibrosis (PMF), and its deletion has also been detected in patient samples of PMF.
== Interactions == NOL3 has been shown to interact with SFRS9 and Caspase 8.
Isoform 1 may be involved in RNA splicing.
NOL3 is also known as ARC, FCM, MYOCL1, MYP, NOP, NOP30.
