NUDT5
Description
The NUDT5 (nudix hydrolase 5) is a protein-coding gene located on chromosome 10.
ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.
NUDT5 acts as an ADP-sugar pyrophosphatase in the absence of diphosphate, hydrolyzing various modified nucleoside diphosphates like ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP, and 8-oxo-dGDP. It can also hydrolyze other nucleotide sugars with low activity. In the presence of diphosphate, NUDT5 catalyzes the synthesis of ATP in the nucleus by converting ADP-ribose to ATP and ribose 5-phosphate. This nuclear ATP synthesis occurs when NUDT5 is dephosphorylated at Thr-45 and is crucial for energy-consuming chromatin remodeling events. NUDT5 does not participate in U8 snoRNA decapping but binds to U8 snoRNA.
NUDT5 is also known as YSA1, YSA1H, YSAH1, hNUDT5.
