NXPH1
Description
The NXPH1 (neurexophilin 1) is a protein-coding gene located on chromosome 7.
NXPH1 is a gene responsible for encoding the protein Neurexophilin-1 in humans. This protein belongs to the neurexophilin family and is secreted. Its structure features a variable N-terminal region, a highly conserved, glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. Notably, Neurexophilin-1 forms a very stable complex with alpha-neurexins, proteins crucial for promoting adhesion between dendrites and axons.
NXPH1 may function as a signaling molecule, similar in nature to neuropeptides. It interacts with alpha-neurexins, potentially binding to other receptors as well.
NXPH1 is also known as NPH1, Nbla00697.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 61
- spermatogenic failure 48
- spermatogenic failures 50
- spermatogenic failure 26
- spermatogenic failure 31
- spermatogenic failure 20
- spermatogenic failure 5
- spermatogenic failure 23
- spermatogenic failure 52
- spermatogenic failure 25
- congenital bilateral absence of vas deferens
- spermatogenic failure 1
- spermatogenic failure 3
- spermatogenic failure 49
- spermatogenic failure 19
