OARD1
Description
The OARD1 (O-acyl-ADP-ribose deacylase 1) is a protein-coding gene located on chromosome 6.
OARD1 is an ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on various substrates, including proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically, it functions as a glutamate mono-ADP-ribosylhydrolase, removing mono-ADP-ribose attached to glutamate residues on proteins. OARD1 does not act on poly-ADP-ribosylated proteins; the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must be hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Additionally, OARD1 deacetylates O-acetyl-ADP-ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose, and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate, and butyrate, respectively.
OARD1 is also known as C6orf130, TARG1, dJ34B21.3.
