OCIAD1
Description
The OCIAD1 (OCIA domain containing 1) is a protein-coding gene located on chromosome 4.
OCIAD1 maintains stem cell potency, possibly by regulating signaling pathways. It increases STAT3 phosphorylation, controls ERK phosphorylation, and may act as a scaffold to enhance STAT3 recruitment to endosomes. This protein is involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer.
OCIAD1 is also known as ASRIJ, OCIA, TPA018.
Associated Diseases
- primary familial polycythemia due to EPO receptor mutation
- alpha thalassemia-intellectual disability syndrome type 1
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- erythrocytosis, familial, 6
- erythrocytosis, familial, 3
- beta-thalassemia-X-linked thrombocytopenia syndrome
