OSTC
Description
The OSTC (oligosaccharyltransferase complex non-catalytic subunit) is a protein-coding gene located on chromosome 4.
OSTC may refer to: Oligosaccharyltransferase complex subunit OSTC, also know as Hydrophobic protein HSF-28.
OSTC, also known as Hydrophobic protein HSF-28, is a specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex. This complex catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. This process is the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally, and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for maximal enzyme activity. OSTC may be involved in N-glycosylation of APP (amyloid-beta precursor protein) and can modulate gamma-secretase cleavage of APP by enhancing endoproteolysis of PSEN1.
OSTC is also known as DC2.
