OTUD6A
Description
The OTUD6A (OTU deubiquitinase 6A) is a protein-coding gene located on chromosome X.
OTUD6A acts as a deubiquitinating enzyme, capable of breaking down various types of polyubiquitin chains attached to proteins. Specifically, it can hydrolyze 'Lys-27'-, 'Lys-29'-, and 'Lys-33'-linked polyubiquitin chains, as well as 'Lys-11'-linked ubiquitin chains. This process helps regulate the stability and function of proteins by removing ubiquitin tags.
OTUD6A is also known as DUBA2, HSHIN6.
Associated Diseases
- cancer
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- linear and whorled nevoid hypermelanosis
- homozygous familial hypercholesterolemia
- sitosterolemia
- thyroid hormone metabolism, abnormal, 2
- neutropenia, severe congenital, 1, autosomal dominant
- familial apolipoprotein C-II deficiency
- cryopyrin-associated periodic syndrome
- urinary bladder carcinoma
