PAG1
Description
The PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1) is a protein-coding gene located on chromosome 8.
PAG1 (Phosphoprotein associated with glycosphingolipid-enriched microdomains 1) is a protein encoded by the PAG1 gene in humans. It functions as a type III transmembrane adaptor protein that binds to the tyrosine kinase CSK. PAG1 is believed to be involved in regulating T cell activation. It interacts with various proteins including FYN, C-src tyrosine kinase, Sodium-hydrogen antiporter 3 regulator 1, and Abl gene.
PAG1 negatively regulates signaling pathways in immune cells. It inhibits T-cell receptor (TCR) signaling in T cells and Fc epsilon receptor 1 (FCER1) signaling in mast cells. PAG1 achieves this by promoting the activation and recruitment of CSK (C-terminal Src kinase) to lipid rafts, leading to the inhibition of LCK (lymphocyte-specific protein tyrosine kinase). Additionally, PAG1 prevents the proper organization of lipid raft proteins, hindering the formation of the immunological synapse, a crucial structure for immune cell communication. PAG1 may also play a role in cell adhesion signaling.
PAG1 is also known as CBP, PAG.
