PATZ1
Description
The PATZ1 (POZ/BTB and AT hook containing zinc finger 1) is a protein-coding gene located on chromosome 22.
PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a human protein encoded by the PATZ1 gene. It contains an AT-hook DNA binding motif, a POZ domain for protein-protein interaction, and zinc fingers for DNA binding. PATZ1 is believed to be a transcriptional repressor. In small round cell sarcoma, the PATZ1 gene is fused to EWS through a chromosomal rearrangement, potentially contributing to tumor development. Four alternatively spliced transcript variants have been identified for this gene. PATZ1 has been shown to interact with the androgen receptor, microphthalmia-associated transcription factor, and RNF4.
PATZ1 is a transcriptional regulator involved in a variety of biological processes including embryogenesis, senescence, T-cell development, and neurogenesis. It interacts with the TP53 protein, inhibiting its DNA binding and transcriptional activity, which regulates genes important for proliferation and DNA damage response. PATZ1 plays a role in the transcriptional network that modulates regulatory T-cell development and controls the generation of regulatory T-cell pool under homeostatic conditions.
PATZ1 is also known as MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23.
Associated Diseases
- skin squamous cell carcinoma
- urinary bladder carcinoma
- carcinoma of liver and intrahepatic biliary tract
