PGP
Description
The PGP (phosphoglycolate phosphatase) is a protein-coding gene located on chromosome 16.
PGP, or Pgp, can refer to several things, including a protein, a pregnancy discomfort, a genome sequencing project, and a computer program for data encryption. In the context of human genes, PGP likely refers to the protein, P-glycoprotein, which plays a role in transporting substances across cell membranes.
Glycerol-3-phosphate phosphatase hydrolyzes glycerol-3-phosphate into glycerol, regulating cellular levels of glycerol-3-phosphate, a metabolic intermediate in glucose, lipid, and energy metabolism. It also exhibits 2-phosphoglycolate phosphatase and tyrosine-protein phosphatase activities, although their physiological significance is unclear (PubMed:26755581). In vitro, it displays phosphatase activity toward ADP, ATP, GDP, and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581}
PGP is also known as AUM, G3PP, PGPase.
Associated Diseases
- lysosomal storage disease
- bipolar disorder
- Alzheimer disease
- type 2 diabetes mellitus
- aplastic anemia
- breast cancer
