TRADD
Description
The TRADD (TNFRSF1A associated via death domain) is a protein-coding gene located on chromosome 16.
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. TRADD is an adaptor protein.
== Function == The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-κB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
TRADD is an adapter molecule that specifically binds to the cytoplasmic domain of activated TNFRSF1A/TNFR1, facilitating its interaction with FADD. Overexpression of TRADD results in two primary TNF-induced responses: apoptosis and activation of NF-kappa-B. The nuclear form of TRADD functions as a tumor suppressor by inhibiting the ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. This suppression is achieved through TRADD's interaction with TRIP12, disrupting the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A.
TRADD is also known as Hs.89862.
Associated Diseases
- early-onset zonular cataract
- cataract 5 multiple types
- isolated agammaglobulinemia
- common variable immunodeficiency
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 3
- hyper-IgM syndrome type 5
- immunodeficiency, common variable, 4
- immunodeficiency, common variable, 7
- BENTA disease
- severe combined immunodeficiency due to CTPS1 deficiency
