TRIM29
Description
The TRIM29 (tripartite motif containing 29) is a protein-coding gene located on chromosome 11.
TRIM29 is a protein encoded by the TRIM29 gene in humans. It belongs to the TRIM protein family and possesses multiple zinc finger motifs and a leucine zipper motif. TRIM29 is believed to form homo- or heterodimers, which are involved in nucleic acid binding, potentially acting as a transcriptional regulatory factor in carcinogenesis and/or differentiation. It might also function in suppressing radiosensitivity due to its association with ataxia-telangiectasia phenotype. TRIM29 has been observed to interact with TRIM23 and GCC1.
TRIM29 plays a crucial role in regulating macrophage activation in response to viral or bacterial infections in the respiratory tract. It achieves this by interacting with IKBKG/NEMO in the lysosome, inducing its 'Lys-48' ubiquitination and subsequent degradation. This inhibition of IKBKG/NEMO leads to a decrease in the expression of type I interferons and pro-inflammatory cytokines. TRIM29 also induces the 'Lys-48' ubiquitination of STING1, leading to its degradation, further contributing to the regulation of immune responses.
TRIM29 is also known as ATDC.
