TRIM34
Description
The TRIM34 (tripartite motif containing 34) is a protein-coding gene located on chromosome 11.
TRIM34 functions as an antiviral protein, contributing to defense against retroviral infections. It acts as a capsid-specific restriction factor, collaborating with TRIM5 to prevent infection from non-host-adapted retroviruses. During influenza A virus infection, TRIM34 promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination, leading to ZBP1 recruitment of RIPK3 and virus-induced programmed necrosis. TRIM34 negatively regulates mitochondrial function by enhancing mitochondrial depolarization, resulting in cytochrome c release and mitochondria-dependent apoptosis. It also promotes the formation of multinucleated giant cells through cell fusion and phagocytosis in epithelial cells.
TRIM34 is also known as IFP1, RNF21.
