TRIM35
Description
The TRIM35 (tripartite motif containing 35) is a protein-coding gene located on chromosome 8.
TRIM35 is an E3 ubiquitin ligase involved in a variety of cellular processes including apoptosis, glucose metabolism, and innate immunity. It plays a role in promoting type I interferon production through RIG-I signaling by mediating Lys-63-linked polyubiquitination of TRAF3. TRIM35 can also catalyze Lys-48-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. TRIM35 acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling by promoting Lys-48-linked ubiquitination of IRF7 and inducing its degradation through a proteasome-dependent pathway. Additionally, TRIM35 reduces FGFR1-dependent tyrosine phosphorylation of PKM, leading to inhibition of PKM-dependent lactate production, glucose metabolism, and cell growth.
TRIM35 is also known as HLS5, MAIR.
