TRIM38
Description
The TRIM38 (tripartite motif containing 38) is a protein-coding gene located on chromosome 6.
TRIM38 is a protein encoded by the TRIM38 gene in humans. It belongs to the tripartite motif (TRIM) family and contains a RING-type zinc finger, B box-type zinc finger, and SPRY domain. While its exact function remains unknown, studies suggest that TRIM38 is involved in regulating innate immunity and may play a role in various cellular processes.
TRIM38 is an E3 ubiquitin-protein and E3 SUMO-protein ligase that plays a significant role in regulating innate immunity. It acts as a negative regulator of type I interferon (IFN-β) production by promoting the degradation of AZI2/NAP1 through 'Lys-48'-linked polyubiquitination. Additionally, TRIM38 inhibits TLR3-mediated type I interferon signaling by mediating the ubiquitination and degradation of the TLR adapter TICAM1. Interestingly, TRIM38 acts as a positive regulator of the cGAS-STING pathway, promoting innate immune response to DNA viruses by mediating the sumoylation of CGAS and STING, preventing their degradation. Furthermore, TRIM38 negatively regulates NF-κB signaling by promoting the lysosome-dependent degradation of TAB2 and TAB3 adapters, independently of its E3 protein ligase activity.
TRIM38 is also known as RNF15, RORET.
