TRIM41
Description
The TRIM41 (tripartite motif containing 41) is a protein-coding gene located on chromosome 5.
Tripartite motif-containing protein 41 (TRIM41) is a protein encoded by the TRIM41 gene in humans.
TRIM41 is an E3 ubiquitin ligase that plays a crucial role in the innate antiviral response. It directly binds to viral nucleoproteins from influenza A and vesicular stomatitis viruses, tagging them for ubiquitination and subsequent degradation by the proteasome, thereby limiting viral infection. TRIM41 activates the innate antiviral response by monoubiquitinating the cyclic GMP-AMP synthase (cGAS), leading to cGAS activation. Additionally, TRIM41 participates in the innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10, which in turn interacts with NEMO to activate the NF-κB and IRF3 pathways. TRIM41 also catalyzes the ubiquitin-mediated degradation of other substrates, including protein kinase C, ZSCAN21, and TOP3B, suggesting roles beyond its immune function.
TRIM41 is also known as RINCK.
