TSPYL2
Description
The TSPYL2 (TSPY like 2) is a protein-coding gene located on chromosome X.
Testis-specific Y-encoded-like protein 2 is a protein encoded by the TSPYL2 gene in humans.
TSPYL2 is part of the CASK/TBR1/TSPYL2 transcriptional complex, which regulates gene expression in response to neural synaptic activity. This complex likely facilitates nucleosome assembly. TSPYL2 may also inhibit cell proliferation by activating p53-dependent CDKN1A expression.
TSPYL2 is also known as CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX.
Associated Diseases
- schizophrenia 15
- cancer
- Phelan-McDermid syndrome
- Potocki-Lupski syndrome
- Smith-Magenis syndrome
- intellectual developmental disorder, X-linked, syndromic, Pilorge type
- FRAXE intellectual disability
- Bloom syndrome
