TST
Description
The TST (thiosulfate sulfurtransferase) is a protein-coding gene located on chromosome 22.
TST, a human gene, can refer to Thiosulfate sulfurtransferase, a protein also known as Rhodanese. It plays a role in forming iron-sulfur complexes, detoxifying cyanide, and modifying sulfur-containing enzymes. TST can accept sulfur ions from various thiol compounds, including cyanide. It also exhibits weak mercaptopyruvate sulfurtransferase (MST) activity. Together with MRPL18, TST acts as a mitochondrial import factor for cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form of TST can bind to 5S rRNA. TST exists as a monomer.
TST is also known as RDS.
Associated Diseases
- 46,XY complete gonadal dysgenesis
- isolated congenital hypogonadotropic hypogonadism
- hemoglobin D disease
- tetragametic chimerism
- 46,XX ovotesticular disorder of sex development
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
- 46,XX testicular disorder of sex development
- partial chromosome Y deletion
- Leydig cell hypoplasia
