TTC3
Description
The TTC3 (tetratricopeptide repeat domain 3) is a protein-coding gene located on chromosome 21.
Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.
TTC3 acts as an E3 ubiquitin ligase, catalyzing the formation of Lys-48-linked polyubiquitin chains. This function leads to the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2, and AKT3) within the nucleus, acting as a terminal regulator of Akt signaling. TTC3's phosphorylation by Akt, which is essential for its ubiquitin ligase activity, suggests a regulatory mechanism for controlling Akt levels after activation. TTC3 also plays a role in regulating neuronal differentiation by controlling actin remodeling and Golgi organization through a signaling pathway involving RHOA, CIT, and ROCK. Additionally, TTC3 positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. TTC3 also inhibits cell proliferation.
TTC3 is also known as DCRR1, RNF105, TPRDIII.
