TTLL12
Description
The TTLL12 (tubulin tyrosine ligase like 12) is a protein-coding gene located on chromosome 22.
TTLL12 negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. It also indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). TTLL12 likely plays a role in mitosis and chromosome number stability by controlling tubulin and/or histone H4 post-translational modifications. During RNA virus-mediated infection, TTLL12 acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
TTLL12 is also known as dJ526I14.2.
