TUSC2
Description
The TUSC2 (tumor suppressor 2, mitochondrial calcium regulator) is a protein-coding gene located on chromosome 3.
The TUSC2 gene encodes a highly conserved protein, Tumor suppressor candidate 2, which is implicated in lung cancer. Limited information is currently available about this gene.
TUSC2 may act as a tumor suppressor by preventing the formation of new cell colonies, halting cell division in the G1 phase, and ultimately leading to programmed cell death in cells lacking the 120-kb region on chromosome 3p21.3.
TUSC2 is also known as C3orf11, FUS1, PAP, PDAP2.
Associated Diseases
- cancer
- autoimmune lymphoproliferative syndrome
- autoinflammatory syndrome with immunodeficiency
- Li-Fraumeni syndrome
- DDX41-related hematologic malignancy predisposition syndrome
- systemic lupus erythematosus
- autoimmune lymphoproliferative syndrome type 2A
- chilblain lupus
- autoimmune lymphoproliferative syndrome type 4
- VEXAS syndrome
- Wiskott-Aldrich syndrome
- autosomal systemic lupus erythematosus type 16
