TYSND1
Description
The TYSND1 (trypsin like peroxisomal matrix peptidase 1) is a protein-coding gene located on chromosome 10.
The TYSND1 gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, facilitating their import into the peroxisome. It also cleaves proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage, generating potentially inactive fragments. Multiple transcript variants exist due to alternative splicing.
TYSND1 is a peroxisomal protease that removes the leader peptide from proteins containing a PTS2 target sequence and also processes several PTS1-containing proteins. It plays a key role in the peroxisomal beta-oxidation of fatty acids by catalyzing the processing of PTS1-proteins involved in this process.
TYSND1 is also known as NET41.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- hemochromatosis type 2A
- spermatogenic failure 42
- spermatogenic failure 65
- spermatogenic failure 51
- spermatogenic failure 72
- spermatogenic failure 39
- spermatogenic failure, X-linked, 3
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 46
- spermatogenic failure 40
- spermatogenic failure 20
- hemochromatosis type 2B
- spermatogenic failure 45
- spermatogenic failure 19
- spermatogenic failure 43
- spermatogenic failure 49
- spermatogenic failure 41
- deafness-infertility syndrome
- severe congenital hypochromic anemia with ringed sideroblasts
