TYW1
Description
The TYW1 (tRNA-yW synthesizing protein 1 homolog) is a protein-coding gene located on chromosome 7.
TYW1 plays a crucial role in the biosynthesis of wybutosine, a modified guanine base found in eukaryotic phenylalanine tRNA. It catalyzes the formation of 4-demethylwyosine, a key intermediate in this process. This reaction involves the condensation of N-methylguanine with two carbon atoms from pyruvate, leading to the creation of the tricyclic 4-demethylwyosine.
TYW1 is also known as RSAFD1, TYW1A, YPL207W.
Associated Diseases
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin D disease
- hemoglobin E disease
- dominant beta-thalassemia
- congenital dyserythropoietic anemia type 4
- saccharopinuria
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
