UBA3
Description
The UBA3 (ubiquitin like modifier activating enzyme 3) is a protein-coding gene located on chromosome 3.
UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme, which activates NEDD8 through a series of steps. First, ATP is used to adenylate the C-terminal glycine residue of NEDD8. Then, this residue is linked to the catalytic cysteine of UBA3, forming a NEDD8-UBA3 thioester and releasing AMP. Finally, NEDD8 is transferred from UBA3 to the catalytic cysteine of UBE2M. UBA3 is involved in down-regulating steroid receptor activity and is necessary for cell cycle progression.
UBA3 is also known as NAE2, UBE1C, hUBA3.
Associated Diseases
- thyroid gland adenocarcinoma
- cancer
- therapy related acute myeloid leukemia and myelodysplastic syndrome
