DNAJC7
Description
The DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7) is a protein-coding gene located on chromosome 17.
DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.
DNAJC7 acts as a co-chaperone, regulating the folding of steroid receptors like the glucocorticoid and progesterone receptors by interacting with the molecular chaperones HSP70 and HSP90. It is proposed to act as a recycling chaperone, facilitating the return of substrates to earlier stages of chaperoning if further folding is required. In laboratory settings, DNAJC7 can detach HSP90 from chaperone-substrate complexes without needing ATP, but it does not detach HSP70. DNAJC7 can move NR1I3 to the cytoplasm.
DNAJC7 is also known as DJ11, DJC7, TPR2, TTC2.
Associated Diseases
- amyotrophic lateral sclerosis
- low grade glioma
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin D disease
- alpha thalassemia-intellectual disability syndrome type 1
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- delta-beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
- dominant beta-thalassemia
- hemoglobin C-beta-thalassemia syndrome
- alpha-thalassemia-myelodysplastic syndrome
- Heinz body anemia
- glycogen storage disease VI
- cirrhosis, familial
