DNTT
Description
The DNTT (DNA nucleotidylexotransferase) is a protein-coding gene located on chromosome 10.
DNTT is a template-independent DNA polymerase that adds deoxynucleoside 5'-triphosphate randomly to the 3'-end of DNA. It plays a critical role in the immune system, specifically in the maturation of B and T cells by adding nucleotides at the junction (N region) of rearranged immunoglobulin heavy chain and T-cell receptor gene segments.
DNTT is also known as TDT.
Associated Diseases
- Okt4 epitope deficiency
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- transient myeloproliferative syndrome
- combined immunodeficiency with skin granulomas
- classic Hodgkin lymphoma
- 22q11.2 deletion syndrome
- thyroid hormone metabolism, abnormal, 2
- sitosterolemia
- seminoma
- homozygous familial hypercholesterolemia
- immunodeficiency 19
- T-cell immunodeficiency, congenital alopecia, and nail dystrophy
