DOK3
Description
The DOK3 (docking protein 3) is a protein-coding gene located on chromosome 5.
Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.
DOK3, a scaffolding protein, facilitates the formation of signaling complexes. It specifically acts as a negative regulator of JNK signaling in B-cells by interacting with INPP5D/SHIP1. Additionally, DOK3 may influence the function of ABL1.
DOK3 is also known as DOKL.
Associated Diseases
- lung cancer
- lymphangioleiomyomatosis
- classic Hodgkin lymphoma
- BAP1-related tumor predisposition syndrome
- immune deficiency, familial variable
- isolated agammaglobulinemia
- hyper-IgM syndrome type 3
- hyper-IgM syndrome type 2
- neutropenia-monocytopenia-deafness syndrome
