DUSP18
Description
The DUSP18 (dual specificity phosphatase 18) is a protein-coding gene located on chromosome 22.
DUSP18 is an enzyme encoded by the DUSP18 gene in humans. It plays a role in regulating cellular processes by removing phosphate groups from proteins.
DUSP18 can remove phosphate groups from single and double-phosphorylated synthetic MAPK peptides, showing a preference for phosphotyrosine and doubly phosphorylated forms over phosphothreonine. Additionally, it can dephosphorylate p-nitrophenyl phosphate (pNPP) in laboratory settings.
DUSP18 is also known as DSP18, DUSP20, LMWDSP20.
Associated Diseases
- schizophrenia 15
- Phelan-McDermid syndrome
- osteopathia striata-pigmentary dermopathy-white forelock syndrome
- Potocki-Lupski syndrome
- uncombable hair syndrome
- Clouston syndrome
- Griscelli syndrome type 3
- white forelock with malformations
- hypotrichosis simplex
- Smith-Magenis syndrome
- intellectual developmental disorder, X-linked, syndromic, Pilorge type
