EMC2
Description
The EMC2 (ER membrane protein complex subunit 2) is a protein-coding gene located on chromosome 8.
EMC2 is a human gene that encodes a protein called Tetratricopeptide repeat protein 35 (TTC35). This protein is a subunit of the ER membrane protein complex (EMC), which plays a vital role in the insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. The process is energy-independent and involves the accommodation of proteins with weakly hydrophobic or destabilizing transmembrane domains. EMC2 participates in both cotranslational and post-translational insertion of membrane proteins, ensuring correct orientation, particularly for multi-pass membrane proteins like G protein-coupled receptors. It also facilitates the post-translational insertion of tail-anchored (TA) proteins into the ER membrane. EMC2 interacts with WNK1, promoting EMC complex assembly by preventing its ubiquitination.
EMC2 is a protein that plays a crucial role in inserting newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. It facilitates this process in an energy-independent manner, accommodating proteins with both weakly hydrophobic and destabilizing transmembrane domains. EMC2 is involved in both cotranslational and post-translational insertion of proteins, ensuring proper orientation of multi-pass membrane proteins, including G protein-coupled receptors. By regulating the insertion of various proteins into membranes, EMC2 indirectly influences a wide range of cellular processes.
EMC2 is also known as KIAA0103, TTC35.
