ENPEP
Description
The ENPEP (glutamyl aminopeptidase) is a protein-coding gene located on chromosome 4.
ENPEP (EC 3.4.11.7), also known as Glutamyl aminopeptidase, Aminopeptidase A, Aspartate aminopeptidase, Angiotensinase A, Glutamyl peptidase, Ca2+-activated glutamate aminopeptidase, Membrane aminopeptidase II, Antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, Angiotensinase A2, and CD249, is an enzyme encoded by the ENPEP gene. This zinc-dependent, membrane-bound aminopeptidase cleaves glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. It degrades the vasoconstricting angiotensin II into angiotensin III, thereby regulating blood pressure.
ENPEP, also known as Glutamyl aminopeptidase (EAP), regulates central hypertension by selectively cleaving N-terminal acidic residues from peptides like angiotensin II. This preference is modulated by calcium.
ENPEP is also known as APA, CD249, gp160.
