EXO5
Description
The EXO5 (exonuclease 5) is a protein-coding gene located on chromosome 1.
EXO5 is a single-stranded DNA (ssDNA) exonuclease that plays a crucial role in DNA repair. It exhibits both 5'-3' and 3'-5' exonuclease activities, with a stronger preference for 5'-ends. EXO5 functions as a sliding exonuclease, loading at the ends of ssDNA and moving along the strand before cleaving it. However, its sliding and 3'-5' exonuclease activities are inhibited upon binding to the Replication Protein A (RPA) complex, which enforces 5'-directionality.
EXO5 is also known as C1orf176, DEM1, Exo V, hExo5.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 8
- partial chromosome Y deletion
- spermatogenic failure 1
- spermatogenic failure 22
- spermatogenic failure 48
- spermatogenic failure 51
- spermatogenic failure 40
- spermatogenic failure, X-linked, 3
- spermatogenic failure 47
- spermatogenic failure 70
- spermatogenic failure 39
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 41
- spermatogenic failure 25
- spermatogenic failure 61
- congenital bilateral absence of vas deferens
- spermatogenic failure 74
- spermatogenic failure 73
- spermatogenic failure 65
- spermatogenic failure 52
