FAM168A
Description
The FAM168A (family with sequence similarity 168 member A) is a protein-coding gene located on chromosome 11.
FAM168A has been implicated in protecting cells from DNA damage and apoptosis in a cancer context. It achieves this, at least partially, through the PI3K/AKT/NFKB signaling pathway and by hindering the degradation of POLB. It reduces the ubiquitylation of POLB, leading to its protein stabilization. This information is supported by several studies: PubMed:21334329, PubMed:21603883, PubMed:23251525, and PubMed:25260657.
FAM168A is also known as KIAA0280, TCRP1.
Associated Diseases
- substance abuse
- X-linked retinoschisis
- X-linked retinal dysplasia
- cancer
- hypoparathyroidism, familial isolated, 2
