FAM89B
Description
The FAM89B (family with sequence similarity 89 member B) is a protein-coding gene located on chromosome 11.
FAM89B plays a role in regulating TGF-beta signaling, preventing the movement of SMAD2 from the nucleus to the cytoplasm. It also acts as a connector, bringing together CDC42BPA and CDC42BPB with LIMK1 at the edge of cells. This connection activates LIMK1, which then modifies CFL1, a protein crucial for the organization of the actin cytoskeleton in these cellular extensions.
FAM89B is also known as LRAP25, MTVR, MTVR1.
