FASTK
Description
The FASTK (Fas activated serine/threonine kinase) is a protein-coding gene located on chromosome 7.
Fas-activated serine/threonine kinase (FASTK) is an enzyme encoded by the FASTK gene in humans. It belongs to the serine/threonine protein kinase family and is rapidly activated during Fas-mediated apoptosis in Jurkat cells. FASTK phosphorylates the apoptosis-promoting nuclear RNA-binding protein TIA1. It is a potent inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms exist: a longer one located in the cell nucleus and cytoplasm, and a shorter one, 34 amino acids shorter at the N-terminus, which is transported to the mitochondrion. The mitochondrial FASTK isoform resides in mitochondrial granules, interacting with the GRSF1 protein and binding to mt-mRNA ND6, the template for the only protein encoded on the light strand of the mitochondrial genome. Deletion of FASTK leads to a loss of ND6 mt-mRNA and a significant decrease in complex I activity of the respiratory chain. Overexpression of FASTK stabilizes ND6 mt-mRNA. Other variants exist, but their full-length nature remains to be determined.
FASTK is also known as FAST.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- cancer
- diabetes mellitus, transient neonatal, 2
- neutropenia, severe congenital, 1, autosomal dominant
- combined immunodeficiency due to moesin deficiency
- agammaglobulinemia 7, autosomal recessive
- hyper-IgM syndrome type 3
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- primary immunodeficiency syndrome due to p14 deficiency
