FBXL14

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Description

The FBXL14 (F-box and leucine rich repeat protein 14) is a protein-coding gene located on chromosome 12.

FBXL14 is a component of certain SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes. This complex specifically targets and promotes the ubiquitination and subsequent degradation of the SNAI1 protein.

FBXL14 is also known as Fbl14.

Associated Diseases

• cancer
• Alzheimer disease
• pachyonychia congenita
• glioblastoma